diff --git a/sdk/cosmosdb/cosmos/src/request/defaultAgent-react-native.mts b/sdk/cosmosdb/cosmos/src/request/defaultAgent-react-native.mts
new file mode 100644
index 000000000000..d6565d17d2bc
--- /dev/null
+++ b/sdk/cosmosdb/cosmos/src/request/defaultAgent-react-native.mts
@@ -0,0 +1,11 @@
+// Copyright (c) Microsoft Corporation.
+// Licensed under the MIT License.
+import type { Agent } from "node:http";
+/**
+ * @hidden
+ */
+export let defaultHttpAgent: Agent;
+/**
+ * @hidden
+ */
+export let defaultHttpsAgent: Agent;
diff --git a/sdk/cosmosdb/cosmos/src/utils/atob-react-native.mts b/sdk/cosmosdb/cosmos/src/utils/atob-react-native.mts
new file mode 100644
index 000000000000..940b04e8ed75
--- /dev/null
+++ b/sdk/cosmosdb/cosmos/src/utils/atob-react-native.mts
@@ -0,0 +1,48 @@
+// Copyright (c) Microsoft Corporation.
+// Licensed under the MIT License.
+
+// Use the same polyfill implementation as browser for React Native
+let safeatob: (data: string) => string;
+
+// base64 character set, plus padding character (=)
+const b64 = "ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=";
+// Regular expression to check formal correctness of base64 encoded strings
+const b64re = /^(?:[A-Za-z\d+/]{4})*?(?:[A-Za-z\d+/]{2}(?:==)?|[A-Za-z\d+/]{3}=?)?$/;
+
+if (typeof atob === "undefined") {
+    // Custom atob implementation for React Native
+    safeatob = (str: string): string => {
+        let fixedStr = String(str).replace(/[\t\n\f\r ]+/g, "");
+        if (!b64re.test(fixedStr)) {
+            throw new TypeError(
+                "Failed to execute 'atob': The string to be decoded is not correctly encoded.",
+            );
+        }
+
+        fixedStr += "==".slice(2 - (fixedStr.length & 3));
+        let bitmap;
+        let result = "";
+        let r1;
+        let r2;
+        let i = 0;
+        for (; i < fixedStr.length;) {
+            bitmap =
+                (b64.indexOf(fixedStr.charAt(i++)) << 18) |
+                (b64.indexOf(fixedStr.charAt(i++)) << 12) |
+                ((r1 = b64.indexOf(fixedStr.charAt(i++))) << 6) |
+                (r2 = b64.indexOf(fixedStr.charAt(i++)));
+
+            result +=
+                r1 === 64
+                    ? String.fromCharCode((bitmap >> 16) & 255)
+                    : r2 === 64
+                        ? String.fromCharCode((bitmap >> 16) & 255, (bitmap >> 8) & 255)
+                        : String.fromCharCode((bitmap >> 16) & 255, (bitmap >> 8) & 255, bitmap & 255);
+        }
+        return result;
+    };
+} else {
+    safeatob = atob;
+}
+
+export default safeatob;
diff --git a/sdk/cosmosdb/cosmos/src/utils/envUtils-react-native.mts b/sdk/cosmosdb/cosmos/src/utils/envUtils-react-native.mts
new file mode 100644
index 000000000000..3d11238bcbbf
--- /dev/null
+++ b/sdk/cosmosdb/cosmos/src/utils/envUtils-react-native.mts
@@ -0,0 +1,4 @@
+// Copyright (c) Microsoft Corporation.
+// Licensed under the MIT License.
+
+export const diagnosticLevelFromEnv: string | undefined = undefined;
diff --git a/sdk/cosmosdb/cosmos/src/utils/hmac-react-native.mts b/sdk/cosmosdb/cosmos/src/utils/hmac-react-native.mts
new file mode 100644
index 000000000000..c88631aea52f
--- /dev/null
+++ b/sdk/cosmosdb/cosmos/src/utils/hmac-react-native.mts
@@ -0,0 +1,20 @@
+// Copyright (c) Microsoft Corporation.
+// Licensed under the MIT License.
+
+import { encodeUTF8, encodeBase64 } from "./encode.js";
+import atob from "./atob.js";
+import { globalCrypto } from "./globalCrypto.js";
+
+export async function hmac(key: string, message: string): Promise<string> {
+    const importParams: HmacImportParams = { name: "HMAC", hash: { name: "SHA-256" } };
+    const encodedMessage = new Uint8Array(
+        [...unescape(encodeURIComponent(message))].map((c) => c.charCodeAt(0)),
+    );
+    const encodedKey = encodeUTF8(atob(key));
+    const cryptoKey = await globalCrypto.subtle.importKey("raw", encodedKey, importParams, false, [
+        "sign",
+    ]);
+    const signature = await globalCrypto.subtle.sign(importParams, cryptoKey, encodedMessage);
+
+    return encodeBase64(signature);
+}