Roadmap for analysis of multipatch experiments

[campagnola]

• NWB browser
  • Summary of sweeps with key parameters (clamp mode, holding cmd)
  • Sweep view
  • Matrix view with averaging, filtering, and artifact removal
• Evoked spike detection for VC and IC
• Distance vs connection probability
  • Depends on ACQ4 / MosaicEditor annotation of cell locations
• Connectivity graph visualization
• Synaptic event properties from averaged traces
  • Exponential deconvolution for analyzing high-frequency inductions
  • Synaptic dynamics characterization from model fitting
• Database storage for analysis results
  • Secondary analyses: connectivity and synaptic properties vs calcium, temperature, and age
• Automated analysis
  • Test pulse analysis for automated QC - measure input/access resistance, holding potential/current
• Synaptic event detection and characterization (spontaneous and evoked)
  • Statistical metrics for detecting connectivity
    • High Pr / low amplitude
    • Low Pr / high amplitude